This is a multi-site focused program of research, funded by the Department of Defense (DoD), awarded to Todd Schwedt, MD (a neurologist at Mayo Clinic). Individual human studies in this focused program include Phenotyping and Neurophysiology; Neuroimaging; Molecular Biomarkers; Clinical Trial; and, Multivariate Modeling. The PVAHCS will participate in the Phenotyping and Neurophysiology project. The purpose of this focused program of research is to help find the cause of post-traumatic headache (PTH) and to determine why PTH goes away relatively quickly in some people, but persists in others. In addition, as there are currently no approved treatments for post-traumatic headache, this program of research will investigate a treatment for PTH with the goal of preventing PTH persistence. This program of research will study the safety and efficacy of a drug called “erenumab” for the treatment of PTH. In children, adults, athletes, civilian, and military populations, PTH closely resembles migraine. Erenumab is approved by the United States Food and Drug Administration for the treatment of migraine and might also be effective for treating PTH.
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